MediaWiki:Common.css

2023-05-18T01:06:32Z

Danesthesia: Undo revision 1908 by Danesthesia (talk)

Zofran (Ondasetron)

2023-05-18T01:06:00Z

Danesthesia:

[[Category:Drug]]
[[Category:Antiemetics]]
[[Category:5-HT3]]

{{infobox drug
| drug_name = zofran
| image = zofran.png
| caption = zofran 4 mg tablet
| type = antiemetic
| used_for = prevention of nausea and vomiting
| atc_code = A04AA01
| legal_status = prescription only
| routes_of_administration = oral, intravenous, intramuscular
| bioavailability = sss
| protein_bound = 70-76%
| metabolism = liver (CYP2D6, CYP3A4)
| elimination_half-life = 3-6 hours
| excretion = kidney (60%), feces (40%)
}}

'''Zofran''' ('''ondansetron''') is an [[antiemetic]] medication used to prevent [[nausea]] and [[vomiting]], particularly in the field of [[anesthesia]]. It is a selective [[5-HT3 receptor antagonist]], which works by blocking the action of [[serotonin]] in the brain and the gastrointestinal tract.

==Route of administration==
* Oral: Disintegrating tablets, film-coated tablets, and oral solution
* Intravenous: Injection
* Intramuscular: Injection

==Dose==
For anesthesia-related nausea and vomiting:
* Adult:
* Oral: 16 mg before anesthesia induction
* Intravenous: 4 mg before anesthesia induction or immediately before/during/after surgery
* Pediatric:
* Oral: 4 mg for children aged 4-11 years, 30-60 minutes before surgery
* Intravenous: 0.1 mg/kg (up to 4 mg) for children aged 1 month-12 years, immediately before/during/after surgery

==Half-life==
* The elimination half-life of ondansetron is approximately 3-6 hours.

==Expected time to work==
* Oral: Onset of action is approximately 30 minutes to 2 hours.
* Intravenous: Onset of action is approximately 5-30 minutes.

==Use in anesthesia==
Zofran is commonly used in anesthesia to:
* Prevent postoperative nausea and vomiting (PONV)
* Prevent nausea and vomiting induced by [[chemotherapy]]
* Prevent nausea and vomiting associated with [[radiation therapy]]

==Side effects==
* Headache
* Fatigue
* Constipation
* Diarrhea
* Dizziness

==Contraindications==
* Hypersensitivity to ondansetron or any component of the formulation
* Concomitant use with [[apomorphine]]
* Patients with congenital long QT syndrome

==Drug interactions==
* [[Serotonin syndrome]] risk may increase when combined with other serotonergic agents (e.g., [[SSRIs]], [[SNRIs]], [[TCAs]], [[MAOIs]], [[triptans]])

==References==
<references />

==External links==
* {{DrugBank|DB00904}}
* {{RxList|Zofran}}
* {{MedlinePlus|a601209}}

[[Category:5-HT3 antagonists]]
[[Category:Antiemetics]]
[[Category:Drugs used in anesthesia]]
[[Category:Carbazoles]]

MediaWiki:Common.css

2023-05-18T01:05:41Z

Danesthesia:

2023-05-18T00:28:47Z

Danesthesia:

2023-05-18T00:16:16Z

Danesthesia:

Template:Infobox drug

2023-05-18T00:09:00Z

Danesthesia:

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{{#if:{{{Au|}}}|<tr>
<th>Au:</th>
<td>{{{Au}}}</td></tr>}}
{{#if:{{{B|}}}|<tr>
<th>B:</th>
<td>{{{B}}}</td></tr>}}
{{#if:{{{Ba|}}}|<tr>
<th>Ba:</th>
<td>{{{Ba}}}</td></tr>}}
{{#if:{{{Be|}}}|<tr>
<th>Be:</th>
<td>{{{Be}}}</td></tr>}}
{{#if:{{{Bh|}}}|<tr>
<th>Bh:</th>
<td>{{{Bh}}}</td></tr>}}
{{#if:{{{Bi|}}}|<tr>
<th>Bi:</th>
<td>{{{Bi}}}</td></tr>}}
{{#if:{{{Bk|}}}|<tr>
<th>Bk:</th>
<td>{{{Bk}}}</td></tr>}}
{{#if:{{{Br|}}}|<tr>
<th>Br:</th>
<td>{{{Br}}}</td></tr>}}
{{#if:{{{C|}}}|<tr>
<th>C:</th>
<td>{{{C}}}</td></tr>}}
{{#if:{{{Ca|}}}|<tr>
<th>Ca:</th>
<td>{{{Ca}}}</td></tr>}}
{{#if:{{{Cd|}}}|<tr>
<th>Cd:</th>
<td>{{{Cd}}}</td></tr>}}
{{#if:{{{Ce|}}}|<tr>
<th>Ce:</th>
<td>{{{Ce}}}</td></tr>}}
{{#if:{{{Cf|}}}|<tr>
<th>Cf:</th>
<td>{{{Cf}}}</td></tr>}}
{{#if:{{{Cl|}}}|<tr>
<th>Cl:</th>
<td>{{{Cl}}}</td></tr>}}
{{#if:{{{Cm|}}}|<tr>
<th>Cm:</th>
<td>{{{Cm}}}</td></tr>}}
{{#if:{{{Cn|}}}|<tr>
<th>Cn:</th>
<td>{{{Cn}}}</td></tr>}}
{{#if:{{{Co|}}}|<tr>
<th>Co:</th>
<td>{{{Co}}}</td></tr>}}
{{#if:{{{Cr|}}}|<tr>
<th>Cr:</th>
<td>{{{Cr}}}</td></tr>}}
{{#if:{{{Cs|}}}|<tr>
<th>Cs:</th>
<td>{{{Cs}}}</td></tr>}}
{{#if:{{{Cu|}}}|<tr>
<th>Cu:</th>
<td>{{{Cu}}}</td></tr>}}
{{#if:{{{D|}}}|<tr>
<th>D:</th>
<td>{{{D}}}</td></tr>}}
{{#if:{{{Db|}}}|<tr>
<th>Db:</th>
<td>{{{Db}}}</td></tr>}}
{{#if:{{{Ds|}}}|<tr>
<th>Ds:</th>
<td>{{{Ds}}}</td></tr>}}
{{#if:{{{Dy|}}}|<tr>
<th>Dy:</th>
<td>{{{Dy}}}</td></tr>}}
{{#if:{{{Er|}}}|<tr>
<th>Er:</th>
<td>{{{Er}}}</td></tr>}}
{{#if:{{{Es|}}}|<tr>
<th>Es:</th>
<td>{{{Es}}}</td></tr>}}
{{#if:{{{Eu|}}}|<tr>
<th>Eu:</th>
<td>{{{Eu}}}</td></tr>}}
{{#if:{{{F|}}}|<tr>
<th>F:</th>
<td>{{{F}}}</td></tr>}}
{{#if:{{{Fe|}}}|<tr>
<th>Fe:</th>
<td>{{{Fe}}}</td></tr>}}
{{#if:{{{Fl|}}}|<tr>
<th>Fl:</th>
<td>{{{Fl}}}</td></tr>}}
{{#if:{{{Fm|}}}|<tr>
<th>Fm:</th>
<td>{{{Fm}}}</td></tr>}}
{{#if:{{{Fr|}}}|<tr>
<th>Fr:</th>
<td>{{{Fr}}}</td></tr>}}
{{#if:{{{Ga|}}}|<tr>
<th>Ga:</th>
<td>{{{Ga}}}</td></tr>}}
{{#if:{{{Gd|}}}|<tr>
<th>Gd:</th>
<td>{{{Gd}}}</td></tr>}}
{{#if:{{{Ge|}}}|<tr>
<th>Ge:</th>
<td>{{{Ge}}}</td></tr>}}
{{#if:{{{H|}}}|<tr>
<th>H:</th>
<td>{{{H}}}</td></tr>}}
{{#if:{{{He|}}}|<tr>
<th>He:</th>
<td>{{{He}}}</td></tr>}}
{{#if:{{{Hf|}}}|<tr>
<th>Hf:</th>
<td>{{{Hf}}}</td></tr>}}
{{#if:{{{Hg|}}}|<tr>
<th>Hg:</th>
<td>{{{Hg}}}</td></tr>}}
{{#if:{{{Ho|}}}|<tr>
<th>Ho:</th>
<td>{{{Ho}}}</td></tr>}}
{{#if:{{{Hs|}}}|<tr>
<th>Hs:</th>
<td>{{{Hs}}}</td></tr>}}
{{#if:{{{I|}}}|<tr>
<th>I:</th>
<td>{{{I}}}</td></tr>}}
{{#if:{{{In|}}}|<tr>
<th>In:</th>
<td>{{{In}}}</td></tr>}}
{{#if:{{{Ir|}}}|<tr>
<th>Ir:</th>
<td>{{{Ir}}}</td></tr>}}
{{#if:{{{K|}}}|<tr>
<th>K:</th>
<td>{{{K}}}</td></tr>}}
{{#if:{{{Kr|}}}|<tr>
<th>Kr:</th>
<td>{{{Kr}}}</td></tr>}}
{{#if:{{{La|}}}|<tr>
<th>La:</th>
<td>{{{La}}}</td></tr>}}
{{#if:{{{Li|}}}|<tr>
<th>Li:</th>
<td>{{{Li}}}</td></tr>}}
{{#if:{{{Lr|}}}|<tr>
<th>Lr:</th>
<td>{{{Lr}}}</td></tr>}}
{{#if:{{{Lu|}}}|<tr>
<th>Lu:</th>
<td>{{{Lu}}}</td></tr>}}
{{#if:{{{Lv|}}}|<tr>
<th>Lv:</th>
<td>{{{Lv}}}</td></tr>}}
{{#if:{{{Mc|}}}|<tr>
<th>Mc:</th>
<td>{{{Mc}}}</td></tr>}}
{{#if:{{{Md|}}}|<tr>
<th>Md:</th>
<td>{{{Md}}}</td></tr>}}
{{#if:{{{Mg|}}}|<tr>
<th>Mg:</th>
<td>{{{Mg}}}</td></tr>}}
{{#if:{{{Mn|}}}|<tr>
<th>Mn:</th>
<td>{{{Mn}}}</td></tr>}}
{{#if:{{{Mo|}}}|<tr>
<th>Mo:</th>
<td>{{{Mo}}}</td></tr>}}
{{#if:{{{Mt|}}}|<tr>
<th>Mt:</th>
<td>{{{Mt}}}</td></tr>}}
{{#if:{{{N|}}}|<tr>
<th>N:</th>
<td>{{{N}}}</td></tr>}}
{{#if:{{{Na|}}}|<tr>
<th>Na:</th>
<td>{{{Na}}}</td></tr>}}
{{#if:{{{Nb|}}}|<tr>
<th>Nb:</th>
<td>{{{Nb}}}</td></tr>}}
{{#if:{{{Nd|}}}|<tr>
<th>Nd:</th>
<td>{{{Nd}}}</td></tr>}}
{{#if:{{{Ne|}}}|<tr>
<th>Ne:</th>
<td>{{{Ne}}}</td></tr>}}
{{#if:{{{Nh|}}}|<tr>
<th>Nh:</th>
<td>{{{Nh}}}</td></tr>}}
{{#if:{{{Ni|}}}|<tr>
<th>Ni:</th>
<td>{{{Ni}}}</td></tr>}}
{{#if:{{{No|}}}|<tr>
<th>No:</th>
<td>{{{No}}}</td></tr>}}
{{#if:{{{Np|}}}|<tr>
<th>Np:</th>
<td>{{{Np}}}</td></tr>}}
{{#if:{{{O|}}}|<tr>
<th>O:</th>
<td>{{{O}}}</td></tr>}}
{{#if:{{{Og|}}}|<tr>
<th>Og:</th>
<td>{{{Og}}}</td></tr>}}
{{#if:{{{Os|}}}|<tr>
<th>Os:</th>
<td>{{{Os}}}</td></tr>}}
{{#if:{{{P|}}}|<tr>
<th>P:</th>
<td>{{{P}}}</td></tr>}}
{{#if:{{{Pa|}}}|<tr>
<th>Pa:</th>
<td>{{{Pa}}}</td></tr>}}
{{#if:{{{Pb|}}}|<tr>
<th>Pb:</th>
<td>{{{Pb}}}</td></tr>}}
{{#if:{{{Pd|}}}|<tr>
<th>Pd:</th>
<td>{{{Pd}}}</td></tr>}}
{{#if:{{{Pm|}}}|<tr>
<th>Pm:</th>
<td>{{{Pm}}}</td></tr>}}
{{#if:{{{Po|}}}|<tr>
<th>Po:</th>
<td>{{{Po}}}</td></tr>}}
{{#if:{{{Pr|}}}|<tr>
<th>Pr:</th>
<td>{{{Pr}}}</td></tr>}}
{{#if:{{{Pt|}}}|<tr>
<th>Pt:</th>
<td>{{{Pt}}}</td></tr>}}
{{#if:{{{Pu|}}}|<tr>
<th>Pu:</th>
<td>{{{Pu}}}</td></tr>}}
{{#if:{{{Ra|}}}|<tr>
<th>Ra:</th>
<td>{{{Ra}}}</td></tr>}}
{{#if:{{{Rb|}}}|<tr>
<th>Rb:</th>
<td>{{{Rb}}}</td></tr>}}
{{#if:{{{Re|}}}|<tr>
<th>Re:</th>
<td>{{{Re}}}</td></tr>}}
{{#if:{{{Rf|}}}|<tr>
<th>Rf:</th>
<td>{{{Rf}}}</td></tr>}}
{{#if:{{{Rg|}}}|<tr>
<th>Rg:</th>
<td>{{{Rg}}}</td></tr>}}
{{#if:{{{Rh|}}}|<tr>
<th>Rh:</th>
<td>{{{Rh}}}</td></tr>}}
{{#if:{{{Rn|}}}|<tr>
<th>Rn:</th>
<td>{{{Rn}}}</td></tr>}}
{{#if:{{{Ru|}}}|<tr>
<th>Ru:</th>
<td>{{{Ru}}}</td></tr>}}
{{#if:{{{S|}}}|<tr>
<th>S:</th>
<td>{{{S}}}</td></tr>}}
{{#if:{{{Sb|}}}|<tr>
<th>Sb:</th>
<td>{{{Sb}}}</td></tr>}}
{{#if:{{{Sc|}}}|<tr>
<th>Sc:</th>
<td>{{{Sc}}}</td></tr>}}
{{#if:{{{Se|}}}|<tr>
<th>Se:</th>
<td>{{{Se}}}</td></tr>}}
{{#if:{{{Sg|}}}|<tr>
<th>Sg:</th>
<td>{{{Sg}}}</td></tr>}}
{{#if:{{{Si|}}}|<tr>
<th>Si:</th>
<td>{{{Si}}}</td></tr>}}
{{#if:{{{Sm|}}}|<tr>
<th>Sm:</th>
<td>{{{Sm}}}</td></tr>}}
{{#if:{{{Sn|}}}|<tr>
<th>Sn:</th>
<td>{{{Sn}}}</td></tr>}}
{{#if:{{{Sr|}}}|<tr>
<th>Sr:</th>
<td>{{{Sr}}}</td></tr>}}
{{#if:{{{Ta|}}}|<tr>
<th>Ta:</th>
<td>{{{Ta}}}</td></tr>}}
{{#if:{{{Tb|}}}|<tr>
<th>Tb:</th>
<td>{{{Tb}}}</td></tr>}}
{{#if:{{{Tc|}}}|<tr>
<th>Tc:</th>
<td>{{{Tc}}}</td></tr>}}
{{#if:{{{Te|}}}|<tr>
<th>Te:</th>
<td>{{{Te}}}</td></tr>}}
{{#if:{{{Th|}}}|<tr>
<th>Th:</th>
<td>{{{Th}}}</td></tr>}}
{{#if:{{{Ti|}}}|<tr>
<th>Ti:</th>
<td>{{{Ti}}}</td></tr>}}
{{#if:{{{Tl|}}}|<tr>
<th>Tl:</th>
<td>{{{Tl}}}</td></tr>}}
{{#if:{{{Tm|}}}|<tr>
<th>Tm:</th>
<td>{{{Tm}}}</td></tr>}}
{{#if:{{{Ts|}}}|<tr>
<th>Ts:</th>
<td>{{{Ts}}}</td></tr>}}
{{#if:{{{U|}}}|<tr>
<th>U:</th>
<td>{{{U}}}</td></tr>}}
{{#if:{{{V|}}}|<tr>
<th>V:</th>
<td>{{{V}}}</td></tr>}}
{{#if:{{{W|}}}|<tr>
<th>W:</th>
<td>{{{W}}}</td></tr>}}
{{#if:{{{Xe|}}}|<tr>
<th>Xe:</th>
<td>{{{Xe}}}</td></tr>}}
{{#if:{{{Y|}}}|<tr>
<th>Y:</th>
<td>{{{Y}}}</td></tr>}}
{{#if:{{{Yb|}}}|<tr>
<th>Yb:</th>
<td>{{{Yb}}}</td></tr>}}
{{#if:{{{Zn|}}}|<tr>
<th>Zn:</th>
<td>{{{Zn}}}</td></tr>}}
{{#if:{{{Zr|}}}|<tr>
<th>Zr:</th>
<td>{{{Zr}}}</td></tr>}}
{{#if:{{{charge|}}}|<tr>
<th>Charge:</th>
<td>{{{charge}}}</td></tr>}}
{{#if:{{{chemical_formula_ref|}}}|<tr>
<th>Chemical Formula Ref:</th>
<td>{{{chemical_formula_ref}}}</td></tr>}}
{{#if:{{{chemical_formula_comment|}}}|<tr>
<th>Chemical Formula Comment:</th>
<td>{{{chemical_formula_comment}}}</td></tr>}}
{{#if:{{{molecular_weight|}}}|<tr>
<th>Molecular Weight:</th>
<td>{{{molecular_weight}}}</td></tr>}}
{{#if:{{{molecular_weight_round|}}}|<tr>
<th>Molecular Weight Round:</th>
<td>{{{molecular_weight_round}}}</td></tr>}}
{{#if:{{{molecular_weight_unit|}}}|<tr>
<th>Molecular Weight Unit:</th>
<td>{{{molecular_weight_unit}}}</td></tr>}}
{{#if:{{{molecular_weight_ref|}}}|<tr>
<th>Molecular Weight Ref:</th>
<td>{{{molecular_weight_ref}}}</td></tr>}}
{{#if:{{{molecular_weight_comment|}}}|<tr>
<th>Molecular Weight Comment:</th>
<td>{{{molecular_weight_comment}}}</td></tr>}}
{{#if:{{{Jmol|}}}|<tr>
<th>Jmol:</th>
<td>{{{Jmol}}}</td></tr>}}
{{#if:{{{Jmol2|}}}|<tr>
<th>Jmol2:</th>
<td>{{{Jmol2}}}</td></tr>}}
{{#if:{{{SMILES|}}}|<tr>
<th>SMILES:</th>
<td>{{{SMILES}}}</td></tr>}}
{{#if:{{{SMILES2|}}}|<tr>
<th>SMILES2:</th>
<td>{{{SMILES2}}}</td></tr>}}
{{#if:{{{chirality|}}}|<tr>
<th>Chirality:</th>
<td>{{{chirality}}}</td></tr>}}
{{#if:{{{specific_rotation|}}}|<tr>
<th>Specific Rotation:</th>
<td>{{{specific_rotation}}}</td></tr>}}
{{#if:{{{density|}}}|<tr>
<th>Density:</th>
<td>{{{density}}}</td></tr>}}
{{#if:{{{density_notes|}}}|<tr>
<th>Density Notes:</th>
<td>{{{density_notes}}}</td></tr>}}
{{#if:{{{melting_point|}}}|<tr>
<th>Melting Point:</th>
<td>{{{melting_point}}}</td></tr>}}
{{#if:{{{melting_high|}}}|<tr>
<th>Melting High:</th>
<td>{{{melting_high}}}</td></tr>}}
{{#if:{{{melting_notes|}}}|<tr>
<th>Melting Notes:</th>
<td>{{{melting_notes}}}</td></tr>}}
{{#if:{{{boiling_point|}}}|<tr>
<th>Boiling Point:</th>
<td>{{{boiling_point}}}</td></tr>}}
{{#if:{{{boiling_high|}}}|<tr>
<th>Boiling High:</th>
<td>{{{boiling_high}}}</td></tr>}}
{{#if:{{{boiling_notes|}}}|<tr>
<th>Boiling Notes:</th>
<td>{{{boiling_notes}}}</td></tr>}}
{{#if:{{{solubility|}}}|<tr>
<th>Solubility:</th>
<td>{{{solubility}}}</td></tr>}}
{{#if:{{{sol_units|}}}|<tr>
<th>Solubility Units:</th>
<td>{{{sol_units}}}</td></tr>}}
{{#if:{{{StdInChI|}}}|<tr>
<th>StdInChI:</th>
<td>{{{StdInChI}}}</td></tr>}}
{{#if:{{{StdInChI2|}}}|<tr>
<th>StdInChI2:</th>
<td>{{{StdInChI2}}}</td></tr>}}
{{#if:{{{StdInChI_Ref|}}}|<tr>
<th>StdInChI Ref:</th>
<td>{{{StdInChI_Ref}}}</td></tr>}}
{{#if:{{{StdInChI_comment|}}}|<tr>
<th>StdInChI Comment:</th>
<td>{{{StdInChI_comment}}}</td></tr>}}
{{#if:{{{StdInChIKey|}}}|<tr>
<th>StdInChIKey:</th>
<td>{{{StdInChIKey}}}</td></tr>}}
{{#if:{{{StdInChIKey_Ref|}}}|<tr>
<th>StdInChIKey Ref:</th>
<td>{{{StdInChIKey_Ref}}}</td></tr>}}
{{#if:{{{StdInChIKey2|}}}|<tr>
<th>StdInChIKey2:</th>
<td>{{{StdInChIKey2}}}</td></tr>}}
{{#if:{{{StdInChIKey2_Ref|}}}|<tr>
<th>StdInChIKey2 Ref:</th>
<td>{{{StdInChIKey2_Ref}}}</td></tr>}}
{{#if:{{{data page|}}}|<tr>
<th>Data Page:</th>
<td>{{{data page}}}</td></tr>}}
{{#if:{{{Verifiedfields|}}}|<tr>
<th>Verified Fields:</th>
<td>{{{Verifiedfields}}}</td></tr>}}
{{#if:{{{verifiedrevid|}}}|<tr>
<th>Verified Revision ID:</th>
<td>{{{verifiedrevid}}}</td></tr>}}
{{#if:{{{container_only|}}}|<tr>
<th>Container Only:</th>
<td>{{{container_only}}}</td></tr>}}
{{#if:{{{licence_CA|}}}|<tr>
<th>Licence CA:</th>
<td>{{{licence_CA}}}</td></tr>}}
{{#if:{{{license_CA|}}}|<tr>
<th>License CA:</th>
<td>{{{license_CA}}}</td></tr>}}
{{#if:{{{QID|}}}|<tr>
<th>QID:</th>
<td>{{{QID}}}</td></tr>}}
{{#if:{{{QID2|}}}|<tr>
<th>QID2:</th>
<td>{{{QID2}}}</td></tr>}}
{{#if:{{{Watchedfields|}}}|<tr>
<th>Watched Fields:</th>
<td>{{{Watchedfields}}}</td></tr>}}
</table>
</div>
<noinclude>
<templatedata>
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"PubChemSubstance2": {},
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"DrugBank2": {},
"DrugBank2_Ref": {},
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"ChemSpiderID2_Ref": {},
"UNII": {},
"UNIIRef": {},
"UNII2": {},
"UNII2_Ref": {},
"KEGG": {},
"KEGG_Ref": {},
"KEGG2": {},
"KEGG2_Ref": {},
"ChEBI": {},
"ChEBI_Ref": {},
"ChEBI2": {},
"ChEBI2_Ref": {},
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"ChEMBL2_Ref": {},
"NIAID_ChemDB": {},
"NIAID_ChemDB2": {},
"PDB_ligand": {},
"PDB_ligand2": {},
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"chemical_formula": {},
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"Rh": {},
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}
</templatedata></noinclude>

2023-05-18T00:01:19Z

Danesthesia:

Zofran (Ondasetron)

2023-05-16T13:10:21Z

Danesthesia:

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{{Infobox drug|INN=asdf|drug_name=asdf|width=a}}
[[Category:Drug]]
[[Category:Antiemetics]]
[[Category:5-HT3]]
==Route of administration==

{{Infobox|anestheticplana=asfd|anestheticplanb=asdf|position=asdf}}

*Intramuscular: Injection

==Dose==
For anesthesia-related nausea and vomiting:
* Adult:
* Oral: 16 mg before anesthesia induction
* Intravenous: 4 mg before anesthesia induction or immediately before/during/after surgery
*Pediatric:
* Oral: 4 mg for children aged 4-11 years, 30-60 minutes before surgery
* Intravenous: 0.1 mg/kg (up to 4 mg) for children aged 1 month-12 years, immediately before/during/after surgery

==Half-life==
*The elimination half-life of ondansetron is approximately 3-6 hours.

==Expected time to work==
*Oral: Onset of action is approximately 30 minutes to 2 hours.
*Intravenous: Onset of action is approximately 5-30 minutes.

==Use in anesthesia==
Zofran is commonly used in anesthesia to:
*Prevent postoperative nausea and vomiting (PONV)
*Prevent nausea and vomiting induced by [[chemotherapy]]
*Prevent nausea and vomiting associated with [[radiation therapy]]

==Side effects==
*Headache
*Fatigue
*Constipation
*Diarrhea
*Dizziness

== Contraindications ==
*Hypersensitivity to ondansetron or any component of the formulation
*Concomitant use with [[apomorphine]]
*Patients with congenital long QT syndrome

== Drug interactions==
*[[Serotonin syndrome]] risk may increase when combined with other serotonergic agents (e.g., [[SSRIs]], [[SNRIs]], [[TCAs]], [[MAOIs]], [[triptans]])

==References==
<references />

==External links==
*{{DrugBank|DB00904}}
*{{RxList|Zofran}}
* {{MedlinePlus|a601209}}

[[Category:5-HT3 antagonists]]
[[Category:Antiemetics]]
[[Category:Drugs used in anesthesia]]
[[Category:Carbazoles]]