https://www.anesthesia.wiki/api.php?action=feedcontributions&feedformat=atom&user=Test1 2026-09-28T12:22:03Z User contributions MediaWiki 1.39.3 https://www.anesthesia.wiki/index.php?title=Zofran_(Ondasetron)&diff=1922 2023-05-18T02:39:23Z

<p>Test1: </p> <hr /> <div>[[Category:Drug]]<br /> [[Category:Antiemetics]]<br /> [[Category:5-HT3]]<br /> <br /> {{infobox drug<br /> | drug_name = zofranx<br /> | image = zofran.png<br /> | caption = zofran 4 mg tablet<br /> | type = antiemetic<br /> | used_for = prevention of nausea and vomiting<br /> | atc_code = A04AA01<br /> | legal_status = prescription only<br /> | routes_of_administration = oral, intravenous, intramuscular<br /> | bioavailability = sss<br /> | protein_bound = 70-76%<br /> | metabolism = liver (CYP2D6, CYP3A4)<br /> | elimination_half-life = 3-6 hours<br /> | excretion = kidney (60%), feces (40%)<br /> }}<br /> <br /> '''Zofran''' ('''ondansetron''') is an [[antiemetic]] medication used to prevent [[nausea]] and [[vomiting]], particularly in the field of [[anesthesia]]. It is a selective [[5-HT3 receptor antagonist]], which works by blocking the action of [[serotonin]] in the brain and the gastrointestinal tract.<br /> <br /> ==Route of administration==<br /> * Oral: Disintegrating tablets, film-coated tablets, and oral solution<br /> * Intravenous: Injection<br /> * Intramuscular: Injection<br /> <br /> ==Dose==<br /> For anesthesia-related nausea and vomiting:<br /> * Adult: <br /> * Oral: 16 mg before anesthesia induction<br /> * Intravenous: 4 mg before anesthesia induction or immediately before/during/after surgery<br /> * Pediatric: <br /> * Oral: 4 mg for children aged 4-11 years, 30-60 minutes before surgery<br /> * Intravenous: 0.1 mg/kg (up to 4 mg) for children aged 1 month-12 years, immediately before/during/after surgery<br /> <br /> ==Half-life==<br /> * The elimination half-life of ondansetron is approximately 3-6 hours.<br /> <br /> ==Expected time to work==<br /> * Oral: Onset of action is approximately 30 minutes to 2 hours.<br /> * Intravenous: Onset of action is approximately 5-30 minutes.<br /> <br /> ==Use in anesthesia==<br /> Zofran is commonly used in anesthesia to:<br /> * Prevent postoperative nausea and vomiting (PONV)<br /> * Prevent nausea and vomiting induced by [[chemotherapy]]<br /> * Prevent nausea and vomiting associated with [[radiation therapy]]<br /> <br /> ==Side effects==<br /> * Headache<br /> * Fatigue<br /> * Constipation<br /> * Diarrhea<br /> * Dizziness<br /> <br /> ==Contraindications==<br /> * Hypersensitivity to ondansetron or any component of the formulation<br /> * Concomitant use with [[apomorphine]]<br /> * Patients with congenital long QT syndrome<br /> <br /> ==Drug interactions==<br /> * [[Serotonin syndrome]] risk may increase when combined with other serotonergic agents (e.g., [[SSRIs]], [[SNRIs]], [[TCAs]], [[MAOIs]], [[triptans]])<br /> <br /> ==References==<br /> &lt;references /&gt;<br /> <br /> ==External links==<br /> * {{DrugBank|DB00904}}<br /> * {{RxList|Zofran}}<br /> * {{MedlinePlus|a601209}}<br /> <br /> <br /> [[Category:5-HT3 antagonists]]<br /> [[Category:Antiemetics]]<br /> [[Category:Drugs used in anesthesia]]<br /> [[Category:Carbazoles]]</div>

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