Zofran (Ondasetron)

Zofran (Ondasetron)

drug name:	drugggg
width:	99
alt:	sdfasdf

Zofran (Ondasetron)

Anesthetic Plan A:	fsdg
Anesthetic Plan B:	sgdf
Position	sfg
Length:	sdfg
Estimated Blood Loss:	sdfg
Post-op Pain Level:	sdfg

asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf asdfasfdasdfas asfsadf

Route of administration

• Oral: Disintegrating tablets, film-coated tablets, and oral solution
• Intravenous: Injection
• Intramuscular: Injection

Dose

For anesthesia-related nausea and vomiting:

• Adult:

 * Oral: 16 mg before anesthesia induction
 * Intravenous: 4 mg before anesthesia induction or immediately before/during/after surgery

• Pediatric:

 * Oral: 4 mg for children aged 4-11 years, 30-60 minutes before surgery
 * Intravenous: 0.1 mg/kg (up to 4 mg) for children aged 1 month-12 years, immediately before/during/after surgery

Half-life

• The elimination half-life of ondansetron is approximately 3-6 hours.

Expected time to work

• Oral: Onset of action is approximately 30 minutes to 2 hours.
• Intravenous: Onset of action is approximately 5-30 minutes.

Use in anesthesia

Zofran is commonly used in anesthesia to:

• Prevent postoperative nausea and vomiting (PONV)
• Prevent nausea and vomiting induced by chemotherapy
• Prevent nausea and vomiting associated with radiation therapy

Side effects

• Headache
• Fatigue
• Constipation
• Diarrhea
• Dizziness

Contraindications

• Hypersensitivity to ondansetron or any component of the formulation
• Concomitant use with apomorphine
• Patients with congenital long QT syndrome

Drug interactions

• Serotonin syndrome risk may increase when combined with other serotonergic agents (e.g., SSRIs, SNRIs, TCAs, MAOIs, triptans)

External links

• Template:DrugBank
• Template:RxList
• Template:MedlinePlus