Zofran (Ondasetron): Difference between revisions
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[[Category:5-HT3]] | [[Category:5-HT3]] | ||
{{infobox drug | |||
{{ | | drug_name = zofranx | ||
| | | image = zofran.png | ||
| caption = zofran 4 mg tablet | |||
| | | type = antiemetic | ||
| | | used_for = prevention of nausea and vomiting | ||
| | | atc_code = A04AA01 | ||
| | | legal_status = prescription only | ||
| | | routes_of_administration = oral, intravenous, intramuscular | ||
| | | bioavailability = sss | ||
| | | protein_bound = 70-76% | ||
| | | metabolism = liver (CYP2D6, CYP3A4) | ||
| | | elimination_half-life = 3-6 hours | ||
| | | excretion = kidney (60%), feces (40%) | ||
| | |||
| | |||
}} | }} | ||
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* {{RxList|Zofran}} | * {{RxList|Zofran}} | ||
* {{MedlinePlus|a601209}} | * {{MedlinePlus|a601209}} | ||
[[Category:5-HT3 antagonists]] | [[Category:5-HT3 antagonists]] | ||
Latest revision as of 22:39, 17 May 2023
Zofran (ondansetron) is an antiemetic medication used to prevent nausea and vomiting, particularly in the field of anesthesia. It is a selective 5-HT3 receptor antagonist, which works by blocking the action of serotonin in the brain and the gastrointestinal tract.
Zofran (Ondasetron)
| drug name: | zofranx |
|---|---|
| image: | zofran.png |
| caption: | zofran 4 mg tablet |
| type: | antiemetic |
| routes of administration: | oral, intravenous, intramuscular |
| metabolism: | liver (CYP2D6, CYP3A4) |
| legal status: | prescription only |
| bioavailability: | sss |
| protein bound: | 70-76% |
| elimination half-life: | 3-6 hours |
| excretion: | kidney (60%), feces (40%) |
Route of administration
- Oral: Disintegrating tablets, film-coated tablets, and oral solution
- Intravenous: Injection
- Intramuscular: Injection
Dose
For anesthesia-related nausea and vomiting:
- Adult:
* Oral: 16 mg before anesthesia induction * Intravenous: 4 mg before anesthesia induction or immediately before/during/after surgery
- Pediatric:
* Oral: 4 mg for children aged 4-11 years, 30-60 minutes before surgery * Intravenous: 0.1 mg/kg (up to 4 mg) for children aged 1 month-12 years, immediately before/during/after surgery
Half-life
- The elimination half-life of ondansetron is approximately 3-6 hours.
Expected time to work
- Oral: Onset of action is approximately 30 minutes to 2 hours.
- Intravenous: Onset of action is approximately 5-30 minutes.
Use in anesthesia
Zofran is commonly used in anesthesia to:
- Prevent postoperative nausea and vomiting (PONV)
- Prevent nausea and vomiting induced by chemotherapy
- Prevent nausea and vomiting associated with radiation therapy
Side effects
- Headache
- Fatigue
- Constipation
- Diarrhea
- Dizziness
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation
- Concomitant use with apomorphine
- Patients with congenital long QT syndrome
Drug interactions
References